The following nonprofit organizations are among those that support natural, scenic, and environmental values in the Mammoth Lakes area:
- Andrea Lawrence Institute for Mountains and Rivers: This organization is committed to conserving mountains, rivers and rural communities by integrating natural integrity with economic vitality.
- California Native Plant Society, Bristlecone Chapter: This organization seeks to increase the understanding of California's native flora and to preserve this rich resource for future generations.
- California Trout: This organization seeks to restore wild trout and steelhead and their waters throughout California.
- Eastern Sierra Audubon Society
- Eastern Sierra Interpretive Association: This organization works in cooperation with the Inyo National Forest to promote and enhance the visitor's understanding and enjoyment of the natural, cultural, historic, and recreational resources of the National Forests.
- Eastern Sierra Land Trust: This organization seeks to protect and enhance vital lands in the Eastern Sierra for their scenic, recreational, agricultural, historical, botanical, and wildlife values.
- Eastern Sierra Wildlife Care: This organization is dedicated to helping native wildlife through rehabilitation of injured, ill and orphaned birds, mammals, and reptiles and by furthering public knowledge and appreciation of wildlife through education.
- Friends of the Inyo: This conservation organization is dedicated to preserving the eastern Sierra's unique qualities: its diverse wild lands, scenic beauty, wild rivers, varied flora and fauna, and abundant opportunities for low-impact recreation.
- Mono Lake Committee: This citizen's group is dedicated to protecting and restoring the Mono Basin Ecosystem; educating the public about Mono Lake and the impacts on the environment of excessive water use; and promoting cooperative solutions that protect Mono Lake and meet real water needs without transferring environmental problems to other areas.
- Owens Valley Committee: This citizen action group is dedicated to the protection, restoration and sustainable management of water and land resources affecting the Owens Valley.
- Sequoia Natural History Association: This organization is dedicated to supporting education, interpretation, research, and the natural and historic preservation of Sequoia and Kings Canyon National Parks, Devils Postpile National Monument, Lake Kaweah, and other areas of the National Park System. The Sequoia Natural History Association is committed to enriching the experiences of visitors and promoting public awareness of the significance of national parks through educational programs, publications, and financial support.
- Sequoia Parks Foundation: This organization funds and supports projects that enhance the restoration, conservation, and enjoyment of Sequoia and Kings Canyon National Parks.
- Sierra Club, Toiyabe Chapter, Range of Light Group
- Sierra Nevada Alliance: This organization seeks to protect and restore the natural resources of the Sierra Nevada for future generations while promoting sustainable communities.